1-(2,3-Dichlorophenyl)piperazine Hydrochloride CAS 119532-26-2 Aripiprazole Intermediate Purity ≥99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. is the leading supplier of 1-(2,3-Dichlorophenyl)piperazine Hydrochloride (CAS: 119532-26-2) with high quality, intermediate of Aripiprazole (CAS: 129722-12-9).
Purchase intermediates of Aripiprazole, please contact us by e-mail: alvin@ruifuchem.com
Chemical Name | 1-(2,3-Dichlorophenyl)piperazine Hydrochloride |
Synonyms | 2,3-DCPP HCl; 1-(2,3-Dichlorophenyl)piperazine HCl; Aripiprazole EP Impurity B; Aripiprazole Related Compound C |
CAS Number | 119532-26-2 |
Stock Status | In Stock, Production Capacity 30 MT/Month |
Molecular Formula | C10H12Cl2N2·HCl |
Molecular Weight | 267.58 |
Melting Point | 245.0~247.0℃ |
Storage & Sensitivity | Hygroscopic. Ambient temperatures |
Solubility | Soluble in Water, DMSO and Methanol |
COA & MSDS | Available |
Origin of Product | Shanghai, China |
Product Categories | Pharmaceutical Intermediates |
Brand | Ruifu Chemical |
Item | Specifications |
Appearance | White or Off-White Powder |
Purity / Analysis Method | ≥99.0% (HPLC) |
Loss on Drying | ≤0.50% |
Residue on Ignition | ≤0.10% |
Single Impurity | ≤0.50% |
Total Impurities | ≤1.00% |
Heavy Metals (as Pb) | ≤20ppm |
Infrared Spectrum | Conforms to Structure |
Test Standard | Enterprise Standard |
Usage | Intermediate of Aripiprazole (CAS: 129722-12-9) |
Package: Fluorinated bottle, aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry and well-ventilated warehouse away from incompatible substances. Keep away from direct sunlight; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by sea, by FedEx / DHL Express. Provide fast and reliable delivery.
Hazard Symbols Xi - Irritant
Risk Codes 36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
WGK Germany 3
HS Code 2934 9990.99
Hazard Note Irritant
1-(2,3-Dichlorophenyl)piperazine Hydrochloride (CAS: 119532-26-2) is an important intermediate of Aripiprazole (CAS: 129722-12-9). Aripiprazole is a new kind of highly lipid soluble quinoline derivatives, its pharmacological effects characteristic is that it is not only the postsynaptic dopamine D 2 receptor antagonist, but also the presynaptic dopamine D 2 receptor agonist,it can also excite D 1, D 3, D 4 receptors ; it has dual effect of partial activation or receptor antagonistic on 5-HT 1A receptor; it has a completely antagonistic action on the 5-HT 2A receptor. This feature is different from the first generation, and atypical antipsychotics which belong to the second-generation antipsychotic drugs, and therefore it is called dopamine system stabilizer or third generation antipsychotic. Since it is sold in the market, it is mainly used in clinical schizophrenia, treatment of affective disorders and other psychiatric disorders. According to the literature, aripiprazole has significant effects on schizophrenia positive and negative symptoms and anxiety, depression, cognitive function, while higher safety. It was also reported that the drug can also treat other mental disorders, such as mood disorders manic episodes, senile dementia associated with mental disorders, anxiety disorders, children's behavioral disorders, depression. Nowadays,Bristol-Myers Squibb and Otsuka Pharmaceutical Company announced that the European Union has approved Abilify (aripiprazole) in the treatment of schizophrenia listing application.